Ephedrine is taken orally. What are the short and long-term effects on the body. The use of Ephedrine raises blood pressure, can cause an irregular heart rhythm and may result in sudden cardiac death.
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It is an alkaloid, being a sympathomimetic responsible for inducing activation of the sympathetic nervous system. Ephedrine has been used for centuries in China, and has well documented effects including use as an anti-asthmatic and decongestant.
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It is also a potent bronchodilator. It also helps widen the lung vents, subsequently leading you to breathe more easily.
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Ephedrine is classified as sympathomimetic drug. Despite extensive work in this field, the mechanism of action of ephedrine remains controversial. Initial studies classified ephedrine as indirectly acting sympathomimetic, subsequent studies showed ephedrine acts by mixed action by releasing noradrenaline and by acting directly on receptors.
However, few recent studies on rat have shown predominant this web page action on this web page receptors. Hence, there is ephedra vs ephedrine controversy existing whether ephedrine is directly, indirectly or mixed acting drug. Gurley BJ, Wang P, Gardner SF. Ephedrine-type alkaloid content of nutritional supplements containing Ephedra sinica (Ma-huang) as determined by high performance liquid chromatography.
Young Ephedra vs ephedrine, Gabryszuk M, Ephedrine alternative RA. Ber Dtsch Chem Ges. Bericht uber das Jahr 1894. Chen K, Schmidt CF. The action of ephedrine, the active principle of the Chinese drug Ma Huang. J Pharmacol Exp Ther.
A study of the adrenotropic receptors. Ephedrine, its use in the treatment of vascular hypotension and bronchial asthma. Miller TG, Chen K, Schmidt CF. J Am Med Assoc.
Department of Health and Human Services commissioned a large meta-analysis of ephedra’s safety and efficacy by the RAND Corporation. This study found that ephedra promoted modest short-term weight loss, but there was insufficient data to determine whether it was effective for long-term weight loss or performance enhancement.
The use of ephedrine alkaloids in this study was associated with significant gastrointestinal, psychiatric, and autonomic side effects. Tommy Thompson, the secretary of health and human services, stated that “. These products pose unacceptable health risks, and any consumers who are still using them should stop immediately. Nutraceutical Corporation stated that while they did not intend to restart marketing ephedra, they were concerned about the scope of the FDA’s regulatory action.
Judge Tena Campbell of the Utah Federal District Court ruled that the FDA had not proven that low doses of ephedra alkaloids were unsafe, although she also noted that studies to address the safety of low-dose ephedra would be unethical. Nevertheless, her ruling overturned the ban on the sale of ephedra alkaloids in the state of Utah, and called into question whether the ban could be enforced anywhere in the United States.
Court of Appeals for the Tenth Circuit in Denver, Colorado. On August 17, ephedra vs ephedrine, the Appeals Court upheld ephedra vs ephedrine FDA’s ban of ephedra alkaloids, finding that the 133,000 page administrative record /ephedrine-withdrawal/ by the FDA supported the agency’s finding that ephedra alkaloids ephedra vs ephedrine an unreasonable risk to consumers.
The sale of ephedra alkaloids containing dietary supplements remains illegal in the United States. Ephedra vs ephedrine botanical information, see Ephedra (genus). For the chemical ephedrine, ephedra vs ephedrine ephedrine. Accessed March 15, 2007. Huang (12 Check this out 2010). The Pharmacology of Chinese Herbs, Second Edition. N Engl J Med. Food and Drug Administration.
Retrieved 7 February 2007. Int J Sport Nutr Exerc Metab. Curr Sports Med Rep. Memorial Sloan-Kettering Cancer Center. Retrieved April 11, 2007. Published intractable ephedrine online THIS at Salon. Ephedra vs ephedrine 8 February ephedra vs ephedrine. From the Office of Dietary Supplements at the National Institutes of Health.
Accessed 7 February ephedrine sulphate. Am J Health Syst Pharm. Published May 2004, accessed 7 February ephedra vs ephedrine. Accessed April 10, continue reading. Purchase ephedra vs ephedrine to view full text.
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