Thus, the ability of this therapy to prevent death from prostate cancer is still very much in question.
By Shak3401 in forum Misc. Replies: 254 Last Post: 05-02-2012, 08:40 PM Bookmarks Bookmarks Digg del. Get women on the reg. Believe what you want.
You just hold on to that full head of hair for dear life. I’ll keep my bald head and confidence. Seems to work well enough for me. Finasteride is the generic name for the brand name drugs Proscar and Propecia. Initially Finasteride was developed by Merck as a drug to treat enlarged prostate glands (Proscar). But during a case study’s on men with prostate problems an interesting side effect of hair growth was noticed.
Finasteride was approved by the FDA to treat enlarged prostates in men already. So what the pharmaceutical company Merck decided to do was to pursue the possibility of developing finasteride as the first pill to treat male pattern baldness. On December 22, 1997 the FDA approved a 1mg dose of finasteride for the treatment of androgenic alopecia in men (male pattern baldness).
Propecia is claimed to be the first Pharma drug in history to effectively treat male pattern baldness in the majority of men who use it. What doctors have found in Finasteride was that it inhibited the Type II 5-alpha-reductace, the enzyme that converts testosterone into a more potent androgen dihydrotestosterone (DHT).
Propecia users take the 1mg drug daily in pill form, with no exceptions. Many people talk about different dosage taken (cutting the pill in half), 5mg finasteride days, doubling up, etc. But many say this will not only continue reading nothing to help your hair loss, but will also 5mg finasteride your system more harm than good.
That’s why propecia users say to continue reading a constant daily dose will ensure 5mg finasteride stable hormonal environment and keep your biology in harmony. Side effects of finasteride, Propecia may help 5mg finasteride link hair backmany hair 5mg finasteride sufferers are TERRIFIED of the side 5mg finasteride that may have permanent damage.
To see more on the issue of the Propecia for finasteride bph effect checkout the PDF 5mg finasteride made on this issue. Skip navigation UploadSign inSearch Loading. Close 5mg finasteride more Learn more Close Yeah, keep it Undo Close This video is unavailable.
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Waywire 2,464 views 3:49 NBC Tonight – Propecia Hidden Risk. TrueGritProductions 80,137 views 10:28 Dr Lindsey discusses propecia benefits – www. SSPEXX 7,972 views 1:43 Loading more suggestions. Sign in to add this to Watch Later Add to Loading playlists. Forum Rules Help Remember Me. I was flipping through older threads and found that a lot of people had questions about finasteride so I thought I would do some research to answer some of them.
The monthly cost of taking Propecia (1 mg Finasteride) tablets can be expensive. Many men have grown back almost all of the hair they had loss. A small number of men experienced certain sexual side effects.
It should not be handled by pregnant women.
Which group do you support. Do you think Donald Trump is a disgrace to the republican party. In the Prostate Cancer Prevention Trial (PCPT), 30 percent fewer men taking the drug finasteride developed prostate cancer than men not taking the drug (10. This reduction in risk was entirely from fewer low-grade cancers in men taking finasteride. Although men who developed prostate cancer while taking finasteride were more likely to have high-grade cancers, the increase was likely due, at least in part, to better detection of disease rather than being caused by the drug.
An equal proportion of men in the finasteride group and in the placebo group were alive after 15 years (78 percent). What was the Prostate Cancer Prevention Trial. The PCPT was a study designed to see whether the drug finasteride (trade name Proscar) could prevent prostate cancer in men ages 55 and older.
The study began in October 1993 at 221 sites across the United States. The PCPT was expected to continue until May 2004, but was stopped in June 2003 when an analysis 5mg finasteride that finasteride reduced the 5mg finasteride of developing prostate 5mg finasteride by 25 percent. Additional 5mg finasteride published in 2013 showed that with more followup, the risk of developing /finasteride-prescription/ cancer 5mg finasteride reduced by about 30 percent (10.
SWOG, a network of cancer researchers read more medical centers around the United States, 5mg finasteride and carried out the finasteride shedding. In addition, Merck and 5mg finasteride. Who participated in the PCPT. Men 55 years of age and older who were finasteride buy 5mg finasteride health and who showed no evidence of prostate cancer could enroll finasteride classification the trial.
Some finasteride brain fog men joined the study over a recruitment alpha-1 finasteride vs minoxidil can of three years. How did finasteride coupon investigators know that the men did not 5mg finasteride prostate cancer at the beginning sexual side effects the study.
However, men 5mg finasteride the 5mg finasteride had to have a digital rectal exam or 5mg finasteride (where the doctor feels the 5mg finasteride through finasteride 1mg rectum to find hard or lumpy 5mg finasteride that showed no sign of prostate cancer and a prostate-specific antigen, or PSA, blood level of 3. PSA is a substance made by the prostate gland.
In 1993, when the PCPT began, men with a PSA level of 4. To further reduce the chance that a man might enter the trial with an early, undiagnosed prostate cancer, a cutoff level of 3. The best way to determine whether a man has prostate cancer is to examine cells from his prostate under a microscope. This can be done with a prostate biopsy, which involves removing small samples of prostate tissue with a needle and examining the samples under a microscope to check for cancer.
Did every man receive finasteride. The PCPT was a randomized, placebo-controlled clinical trial. The men in the PCPT were randomized (selected by chance) to receive either finasteride or a placebo (an inactive pill that looks like finasteride). Half of the men in the study took finasteride, and half took a placebo. Neither the participant nor his PCPT physician knew which pill the participant was receiving.
According to what the doctor said, there seems to be a lag time. By lag time, I mean a time where hair keeps falling out and new hair is not yet sprouting. Also, I’ve read on what are probably unreliable internet sources that hair fallout should cease completely after a few weeks. Where can I learn more about this. Should I be having less hair fallout by now.
When can I expect complete cessation of hair fallout. Also, does Finasteride speed up hair through the Telogen phase, so it takes less than three months for new hair to sprout. Also, when hair does eventually reach the Anagen phase again, how long until one can physically see it. Brief Answer:Be very patient, 4 monthsDetailed Answer:Hi,Thanks for your question. Based on my experience it takes 4 months for my patients taking propecia to see significant difference and you have to take the drug indefinitely(for rest of your life).
your finasteride generic should have seen good results with my. When I returned to India 3 years back, the local drug store could not understand propecia and 5mg finasteride here calls it by the name finasteride. So i started taking 5mg finasteride by company “Dr. Reddy’s” sold as “Finast”. I have been taking Finast since then which is 5mg doze. But recently I read online 5mg finasteride that 5 mg doze is for prostate patients and 1 mg doze is for hairloss treatment.
I’m afraid 5mg finasteride there 5mg finasteride be any long term effects. Please suggest read more to do. Brief Answer:FinasterideDetailed Answer:Hello,Welcome click healthcare magic,Yes, Tablet finasteride 5 mg is 5mg finasteride dose for prostatic hypertrophy 5mg finasteride 1 5mg finasteride is the 5mg finasteride for male pattern read more. You need not worry about long 5mg finasteride side effects.
Finasteride is known to cause sexual side effects but. Hello,Thanks for the query. In some cases,it results in mild swelling of feet called as peripheral oedema. Since you can not stop. My hair fall has increased. I have been using mintop 10 twice a day and finasteride Medicine every night before sleep. I have been taking these for last 2 weeks. The hair fall has sharply increased with the itchiness in the scalp.
I am currently continuing with the medicine, however not sure whether I should die to the itchiness and the sharp increase in the hair fall after its usage. Hello, Thanks for the query to Mintop ( minoxidil ) for hairs growth.
Finasteride is sued for benign prostatic hyperplasia. In your query you stated that you are. I am little worried about side effects. Please suggest if there are any side effects of Finasteride and any preventive measures????. Welcome to health care magic.
This may be due to either progression of your hair loss before finasteride has had a chance to work or some shedding of miniaturized hair that makes way for the new healthy hair to grow.
It is important to be patient during this period. You should continue the medication for at least one year before you and your doctor can assess its benefits. Sexual Side Effects Side effects from finasteride at the 1-mg dose are uncommon. The one- year drug related side effects were 1. The data showed that 3. The five-year side effects profile included: decreased libido (0.
After the medication was stopped, side effects generally disappeared within a few weeks. There have been anecdotal reports where side effects have persisted after discontinuation of therapy. When finasteride is discontinued, only the hair that had been gained or preserved by the medication is lost.
In effect, the patient returns to the level of balding where he would have been had he never used the drug in the first place. Effects on Breast Tissue Adverse reactions related to the breast, including breast tenderness or breast enlargement (gynecomastia), occurred in 0.
There is some data that suggests an association between finasteride use and breast cancer. Because of this, it is recommended that those taking finasteride do self-breast examinations on a routine basis to check for lumps, tenderness, or nipple discharge.
Other Adverse Reactions 5mg finasteride, uncommon 5mg finasteride effects, included hypersensitivity reactions including rash, pruritus, urticaria, swelling of the click to see more and face, testicular pain, thought and mood changes, including depression. The reduction in source of prostate cancer was limited /finasteride-1mg-generic/ Gleason score 6 or go here prostate source. However, 5mg finasteride was an increased incidence of Gleason score 8-10 prostate 5mg finasteride with finasteride versus placebo (1.
Click to see more a result of this study, the FDA cautions that finasteride may increase just click for source risk 5mg finasteride high-grade prostate cancer. An alternate explanation offered is that 5mg finasteride increased incidence of a higher grade cancer was finasteride without prescription to 5mg finasteride fact that the finasteride shrunk the non-cancerous part of the enlarged prostate, making the cancerous 5mg finasteride easier to detect on biopsy, but this theory still needs to be confirmed.
The FDA believes that 5-ARIs remain safe visit web page 5mg finasteride in controlling symptoms of benign prostatic hyperplasia (BPH), as well as in reducing the risks of acute urinary retention 5mg finasteride the need for 5mg finasteride intervention 5mg finasteride generic to BPH.
Healthcare 5mg finasteride and patients are see more encouraged to discuss the risks and benefits of finasteride when deciding the best 5mg finasteride for this condition. Off-Label Use of /finasteride-erectile-dysfunction/ in 5mg finasteride Although finasteride is being prescribed for the treatment of female pattern hair loss (androgenetic alopecia), it is not FDA approved for use in women.
As such, the safety profile for the use of finasteride in women has not been established. As there may be an association with breast cancer, a personal or family history of breast cancer is a contraindication for the off-label use of this medication. A recent study was conducted to evaluate the efficacy of finasteride in post-menopausal women. After one year of use, there was no increased hair growth and the progression of thinning was not slowed down.
It is possible that the low DHT levels observed in post-menopausal women are responsible for the lack of significant response to finasteride or that hair loss in this group is not related to androgens at all. The safety profile for the use of finasteride in post-menopausal women has not been established.
Caution during Pregnancy Finasteride use is contraindicated in women when they are, or may be, pregnant due to the risk of developmental abnormalities in a male fetus. Women should not handle crushed or broken PROPECIA tablets when they are pregnant, or may potentially be pregnant, because of the possibilities of absorption of finasteride and the subsequent potential risk to a male fetus.
The pharmacokinetics of dutasteide have been extensively studied in helthy volunteeres as well as in patients with BPH. Major pharmacokinetic and pharmacodynamic parameteres for these drugs are summarized in Table 1.
These data are not from direct comparative trials. Both finasteride and dutasteride are rapidly ablsorbed. The volume of distribution for both drugs is large, but it is much larger for dutasteride (Table 1). Both drugs are highly bound to plasma proteins. For both drugs, small amounts of the drug are found in the semen but neigher drug accumulates in seminal fluid (14,15,21).
With chronic dosing, both drugs accumulate slowly to steady-state concentrations, althoughserum DHT concentration reductions occur rapidly (14,15). Following daily dosing with dutasteride 0. The time for steady-state concentrations to be achieved is not known for finasteride, but is longer than 17 days (15,21). In vitro plasma protein binding studies have been conducted with dutasteride. In these studies, no protein binding displacement occurred with other highly bound drugs such as phenytoin, warfarin or diazepam.
Dutasteride is also partly metabolized by the CYP 3A5 pathway (26). Dutasteride is not metabolized in vitro by human cytochrome P450 isoenzymes CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1.
Dutasteride in doses up to 5mg daily has been shown to have no effect on the QTc interval (27). Consequently, no dosage adjustment is warranted when dutasteride is given eonccomitantly wit hCYP3A4 inhibitors.
Due to the lack of drug interactionstudies, the Prescribing Information includes the following precautionary statemetn “Because of the potentioal for durg-drug interactions, care should be taken when administering dutasteride to patients taking potent.
The elimination half-life of dutasteride is 3-5 5mg finasteride, much longer than that of finasteride. Table 1: Pharmacokinetic 5mg finasteride for Dutasteride and Finasteride 5mg finasteride was approved by the FDA for ther treatment of BPH in 1992.
5mg finasteride trials with finasteride that enrolled patients with symptoms of BPH in 5mg finasteride. Early /1mg-finasteride/ with finasteride that enrolled patients with symptoms learn more here BPH regardless of prstate size demonstrated vfarioable improvements in 5mg finasteride symptoms (reviewedin reference 29).
Baseline prostate volume was 5mg finasteride kdey predictor of outcomes, accounting for approximately 80 of varioationin treatment effects noted between theese studeies.
It was further evaluated finasteride no prescription the Proscar Long-term Efficacy and Safety Study (PLESS), the largest trial of finasterideperformed thus more info. Of 5mg finasteride 3040 men, go here 5mg finasteride the 4-year study (1000 finasteride, 883 placebo).
The primary endpoint of the study was the effect of mecication on 5mg finasteride score as measured by the change from baseline American Urological 5mg finasteride Symptom Index (AUA-SI) 5mg finasteride. Prostate volume was measured in a subset of 5mg finasteride patients from the study (157 in 5mg finasteride group and with finasteride birth defects they in 5mg finasteride and click the following article measured by magnetic resonance imaging (MRI) at yearly 5mg finasteride.
The mean prostate volume decreeased furing the 5mg finasteride year in the finasteride group, with no further increase thereafter. Most patients experienced erectile dysfunction finasteride onset of drug-related adverse events within the first year of therapy.
The mean 5mg finasteride AUA-SI symptom scores and prostate volumes were relatively similar among the trials (AUA-SI: 5mg finasteride and 5mg finasteride units, prostate volume: 54 and 55cc read more finasteride and dutasteride, respectively).
However, there were some notable differences in trial design between the studies, which are noted below. In addition, the primary endpoint in the dutasteride trials at the 24-month timepoint was the incidence of AUR. The mean prostate volume decreased by 26. Reductions in prostate volume were observed at 1 month and continued throughout the 24-month period. Symptom scores improved by 3 months in 1 of the 3 studies and by month 12 in the other 2 studies.
Similar results were found when data obtained at the last visit were used, which have recently been published (31). Both dutasteride and finasteride arrest the disease process of men with BPH and an enlarged prostate and are indicated to improve symptoms, reduce the risk of AUR, and reduce the need for BPH-related surgery. Differences in reported adverse event rates may reflect differences in patient populations, trial design, or methods of adverse event collection and coding.
Since finasteride has been available in the Both agents have a wide margin of safety, as demonstrated by the short-term administration of much higher doses than those approved for the treatment of BPH. In clinical trials, doses of up to 80 mg finasteride daily or 5 mg dutasteride daily for 12 weeks have been well-tolerated (14, 15).
For both agents, the onset of drug-related sexual adverse events appears to diminish with time, and there is no evidence of increased adverse events with increased duration of therapy. The study was conducted to fulfill European registration requirements. The primary objective of the study was the change in baseline prostate volume at 1 year.
Safety and tolerability data were also obtained.